Malignant neoplasm of endocrine pancreas

This code signifies a primary cancerous tumor originating in the endocrine cells of the pancreas, specifically the islet cells (e.g., insulinoma, glucagonoma, VIPoma, somatostatinoma). These tumors are distinct from exocrine pancreatic cancers and often present with hormone-related symptoms.

Apply this code when documentation confirms a primary malignant neoplasm of the pancreatic islets or other endocrine cell types within the pancreas. Supporting documentation should clearly state the malignancy and its endocrine origin, often confirmed by pathology reports or specific hormone assays.

• Differentiate carefully from malignant neoplasms of the exocrine pancreas (C25.0-C25.3, C25.7-C25.9).
• Specify the functional type of the tumor (e.g., insulinoma) if known, using additional codes for associated syndromes or symptoms.
• Ensure the documentation specifies "malignant" as opposed to benign or uncertain behavior, which would map to D13.7 or D37.7.