Diffuse large B-cell lymphoma, spleen

This code signifies a diagnosis of diffuse large B-cell lymphoma (DLBCL) specifically affecting the spleen. DLBCL is an aggressive, fast-growing type of non-Hodgkin lymphoma that originates from B-lymphocytes. When the spleen is the primary or a significant site of involvement, this code is appropriate.

Apply this code when documentation confirms a diagnosis of diffuse large B-cell lymphoma with splenic involvement. This is typically supported by pathology reports from splenic biopsy or splenectomy, imaging studies showing splenic lesions, and clinical notes indicating primary or secondary splenic involvement. Use this code when the spleen is identified as the specific anatomical site of the lymphoma.

• Ensure the documentation explicitly states "diffuse large B-cell lymphoma" and identifies the "spleen" as the affected site.
• Do not use this code for other types of B-cell lymphoma or if the splenic involvement is not specifically documented as DLBCL.
• Always sequence this code as the primary diagnosis when the splenic DLBCL is the reason for the encounter, or as a secondary diagnosis if it's a co-morbidity.