Diffuse large B-cell lymphoma, lymph nodes of multiple sites

This code signifies a diagnosis of diffuse large B-cell lymphoma (DLBCL) that has been identified in multiple lymph node regions throughout the body. DLBCL is an aggressive, fast-growing type of non-Hodgkin lymphoma originating from B-lymphocytes. This specific code indicates widespread nodal involvement without specifying extranodal sites.

Apply this code when documentation clearly states a diagnosis of diffuse large B-cell lymphoma affecting multiple lymph node groups. This typically follows a biopsy and pathological confirmation, along with imaging studies (e.g., PET scan, CT scan) demonstrating multifocal nodal disease. The physician's diagnostic statement must explicitly mention "diffuse large B-cell lymphoma" and "multiple sites" or "multiple lymph nodes."

• Ensure the pathology report confirms "diffuse large B-cell lymphoma" and not another subtype of non-Hodgkin lymphoma.
• Verify that the documentation specifies involvement of multiple lymph node sites, not just a single site or an unspecified site.
• Do not use this code if the lymphoma is described as primarily extranodal, even if some nodal involvement is present; other codes are more appropriate for extranodal presentations.