Acute megakaryoblastic leukemia, in relapse

This diagnosis code signifies a recurrence of acute megakaryoblastic leukemia (AMKL), a rare and aggressive subtype of acute myeloid leukemia (AML) characterized by the proliferation of immature megakaryoblasts. "In relapse" indicates that the disease, after a period of remission, has returned.

This code is appropriate when a patient with a documented history of AMKL presents with evidence of disease recurrence, such as increasing blast counts in the bone marrow or peripheral blood, or extramedullary involvement. Documentation should clearly state "acute megakaryoblastic leukemia in relapse" or similar terminology confirming the return of the disease.

• Distinguish from "in remission" or "not having achieved remission" for AMKL; this code specifically indicates relapse.
• Always sequence this code as the primary diagnosis if the relapse is the reason for the encounter.
• Ensure the medical record explicitly states "relapse" for AMKL to support the use of this specific code.