Refractory anemia with excess of blasts 2

📋Clinical Description

This code signifies a specific subtype of Myelodysplastic Syndromes (MDS) characterized by persistent anemia and an increased percentage of blasts (immature blood cells) in the bone marrow, ranging from 10% to 19%. It indicates a more advanced stage of MDS compared to those with fewer blasts, often associated with a higher risk of progression to acute myeloid leukemia (AML).

🎯When to Use

Apply this code when documentation clearly states a diagnosis of refractory anemia with excess blasts 2 (RAEB-2) based on bone marrow biopsy findings showing 10-19% blasts. This diagnosis is typically made by a hematologist/oncologist following comprehensive blood and bone marrow analysis.

💡Coding Tips

Differentiate from D46.21 (RAEB-1, 5-9% blasts) based on the precise blast percentage documented.
Always confirm the blast percentage in the bone marrow or peripheral blood to ensure accurate subtyping of MDS.
Consider sequencing this code as the primary diagnosis when it is the reason for the encounter, especially for treatment or management of the MDS.

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Clinical Notes

Inclusion Terms

RAEB 2

Code Hierarchy

▲D46.2Refractory anemia with excess of blasts [RAEB]

D46.22(current)

Crosswalks

238.73ApproxICD-9 238.73ApproxICD-9

Same Category

D46Myelodysplastic syndromes D46.0Refractory anemia without ring sideroblasts, so stated D46.1Refractory anemia with ring sideroblasts D46.2Refractory anemia with excess of blasts [RAEB]