Other drug-induced pancytopenia

This code signifies a reduction in all three major blood cell lines (red blood cells, white blood cells, and platelets) caused by an adverse reaction to a medication, but which does not meet the criteria for aplastic anemia. It represents a broader category of drug-induced bone marrow suppression affecting multiple cell types.

Use this code when documentation clearly indicates pancytopenia as a direct consequence of drug therapy, and the physician has ruled out aplastic anemia. This code is appropriate when the bone marrow is suppressed, but not to the extent of complete aplasia.

• Differentiate carefully from D61.1 (aplastic anemia due to drugs); the key distinction is the severity and specific bone marrow findings.
• Always review the patient's medication list and physician's notes for explicit linkage between the drug and the pancytopenia.
• Consider sequencing the drug causing the adverse effect as an additional code (T36-T50 with a 5th or 6th character indicating adverse effect).