Antibody defic w near-norm immunoglob or w hyperimmunoglob

This code describes a primary immunodeficiency characterized by impaired antibody production despite normal or even elevated levels of total immunoglobulins. Patients typically present with recurrent bacterial infections, particularly of the respiratory tract, due to a functional defect in specific antibody responses. This condition is distinct from common variable immunodeficiency (CVID) where total immunoglobulin levels are typically low.

Use this code for patients diagnosed with specific antibody deficiency (SAD) or functional antibody deficiency, often identified through poor vaccine responses (e.g., to pneumococcal polysaccharides) despite normal IgG, IgA, and IgM levels. Documentation should clearly indicate a history of recurrent infections and laboratory evidence of impaired specific antibody production.

• Do not confuse with CVID (D83.0) or other hypogammaglobulinemias where total immunoglobulin levels are low.
• Ensure documentation specifies "near-normal" or "hyperimmunoglobulinemia" in conjunction with antibody deficiency.
• Code any associated recurrent infections (e.g., pneumonia, sinusitis) separately as secondary diagnoses.