Chronic graft-versus-host disease

This code identifies a chronic immune-mediated complication arising from an allogeneic hematopoietic stem cell transplant. It occurs when donor T-cells recognize recipient tissues as foreign, leading to inflammation and damage in various organs, persisting for more than 100 days post-transplant or developing after this period.

Apply this code for patients diagnosed with chronic graft-versus-host disease (cGVHD) following an allogeneic stem cell transplant. Documentation should clearly state the chronicity of the condition, often specifying affected organs (e.g., skin, liver, lungs, gut).

• Always sequence this code after the appropriate transplant status code (e.g., Z94.81 for bone marrow transplant status).
• Code all manifestations of cGVHD separately, linking them to this primary diagnosis.
• Distinguish carefully from acute GVHD (D89.810); the chronicity is key for this code.