Cytokine release syndrome, grade 2

This code signifies a moderate systemic inflammatory response characterized by the release of cytokines, often a side effect of immunotherapy or cellular therapy. Patients typically present with moderate symptoms such as fever, hypotension requiring vasopressors, or hypoxia requiring low-flow oxygen. It represents a specific severity level of this immune-mediated adverse event.

Assign this code when documentation explicitly states "cytokine release syndrome, grade 2" or describes symptoms consistent with this grade, such as fever, hypotension responsive to a single vasopressor, or hypoxia requiring nasal cannula oxygen. This is commonly seen following CAR T-cell therapy or other immunotherapies.

• Always confirm the specific grade of cytokine release syndrome (CRS) from the provider's documentation.
• Do not use for other grades of CRS; separate codes exist for grades 1, 3, 4, and 5.
• Sequence this code after the underlying condition or treatment causing the CRS, if applicable.