Acromegaly and pituitary gigantism

This code represents a hormonal disorder characterized by the excessive production of growth hormone (GH) by the pituitary gland. In adults, this leads to acromegaly, causing enlargement of hands, feet, and facial features. In children and adolescents before epiphyseal plate closure, it results in pituitary gigantism, marked by abnormally tall stature.

Use this code when documentation confirms a diagnosis of acromegaly or pituitary gigantism due to a pituitary adenoma or other pituitary-related cause of GH hypersecretion. This code is appropriate for patients presenting with classic signs and symptoms, elevated GH and IGF-1 levels, and imaging (e.g., MRI of the pituitary) confirming a pituitary lesion.

• Differentiate from constitutional gigantism or tall stature (E34.4), which are non-pathological growth variations.
• Ensure documentation specifies the pituitary as the source of excess growth hormone to distinguish from ectopic GH-releasing hormone secretion.
• Code any underlying pituitary adenoma (e.g., D35.2) as a secondary diagnosis, if applicable and documented.