Megavitamin-B6 syndrome

This code represents a toxic neuropathy resulting from excessive intake of vitamin B6 (pyridoxine). It typically manifests as sensory neuropathy, characterized by numbness, tingling, and pain, primarily in the extremities, and can also include motor weakness and ataxia. The condition is directly linked to chronic, high-dose supplementation of pyridoxine.

Use this code when documentation clearly indicates a diagnosis of neuropathy or other adverse effects directly attributed to megadoses of vitamin B6. This diagnosis is typically made based on patient history of high-dose pyridoxine supplementation and clinical presentation consistent with sensory neuropathy. Documentation should specify the link between the vitamin intake and the symptoms.

• Ensure documentation specifies "megavitamin" or "excessive intake" of B6, not just B6 deficiency or general vitamin toxicity.
• Do not confuse with nutritional deficiencies (e.g., E53.1 for B6 deficiency) or other forms of toxic neuropathy not related to B6.
• Consider sequencing this code as a primary diagnosis when it is the reason for the encounter, or as a secondary diagnosis when it is a co-morbidity being managed.