Disorder of glycine metabolism, unspecified

This code represents an unspecific metabolic error affecting the body's processing of glycine, an amino acid. These disorders can lead to a buildup of glycine in the blood and urine, potentially causing neurological symptoms such as lethargy, seizures, and developmental delays, particularly in infants.

Use this code when documentation indicates a confirmed disorder of glycine metabolism, but the specific type (e.g., nonketotic hyperglycinemia, sarcosine dehydrogenase deficiency) is not specified or definitively diagnosed. This code is appropriate when initial diagnostic workup points to a glycine metabolism issue, but further specificity is lacking.

• Avoid using this code if a more specific disorder of glycine metabolism (e.g., E72.51 for nonketotic hyperglycinemia) is documented.
• Query the provider for greater specificity if possible, as specific diagnoses often lead to more targeted treatment and better data for research.
• Ensure documentation supports a confirmed metabolic disorder, not just elevated glycine levels that could be transient or secondary to other conditions.