Obesity due to disruption of MC4R pathway

This code describes a specific genetic form of obesity resulting from a dysfunction in the melanocortin 4 receptor (MC4R) signaling pathway. This disruption leads to severe early-onset obesity due to impaired satiety and increased food intake. It is a monogenic cause of obesity, distinct from polygenic or lifestyle-induced forms.

Use this code when documentation explicitly states obesity due to a disruption of the MC4R pathway, often confirmed by genetic testing. This diagnosis is typically made in pediatric or adolescent patients presenting with severe, intractable obesity from a young age. Supporting documentation should include genetic test results or a physician's definitive diagnosis linking obesity to MC4R pathway dysfunction.

• Do not use this code for general or unspecified obesity; it requires specific documentation of MC4R pathway disruption.
• Always sequence this code as the primary diagnosis when it is the definitive cause of obesity.
• Consider co-reporting with codes for extreme obesity (e.g., BMI > 40) if applicable, but ensure the MC4R pathway disruption is clearly documented as the etiology.