Limb girdle musc dyst due to anoctamin-5 dysfunction

This code identifies a specific genetic neuromuscular disorder characterized by progressive weakness and wasting of muscles in the shoulders, upper arms, hips, and thighs. It is caused by a genetic mutation affecting the ANO5 gene, leading to dysfunction of the anoctamin-5 protein.

Assign this code for patients diagnosed with limb-girdle muscular dystrophy where genetic testing or clinical presentation confirms anoctamin-5 gene involvement. Documentation should explicitly state "limb-girdle muscular dystrophy due to anoctamin-5 dysfunction" or similar phrasing indicating the specific genetic etiology.

• Ensure documentation specifies the genetic cause (ANO5 dysfunction) to differentiate from other forms of limb-girdle muscular dystrophy.
• Do not use for unspecified limb-girdle muscular dystrophy or other genetically distinct types.
• Consider sequencing with codes for associated symptoms or complications, such as muscle weakness (R25.2) or gait abnormalities (R26.89), if separately documented and treated.