Adverse effect of enzymes, sequela

This code signifies a long-term or residual condition resulting from a past adverse reaction to an enzyme, such as those used in digestive aids or certain therapies. It indicates that the patient is experiencing ongoing health issues directly attributable to a previous, untoward effect of an enzyme.

Use this code when documenting a chronic or permanent sequela following an adverse effect of an enzyme. This would apply, for example, if a patient developed persistent organ damage or a chronic autoimmune condition years after an allergic reaction to an enzyme medication. It is appropriate when the acute adverse event has resolved, but its lasting consequences remain.

• Always sequence this code after the code(s) identifying the specific sequela (e.g., chronic kidney disease, asthma).
• Ensure documentation clearly links the current condition to a past adverse effect of an enzyme.
• Do not use for acute adverse effects; those require codes from the "A" or "D" categories for initial or subsequent encounters.