Progesterone receptor negative status

This code indicates that a tumor or tissue sample has tested negative for the presence of progesterone receptors. This finding is significant in the characterization and treatment planning for certain hormone-sensitive cancers, particularly breast cancer. It suggests the cancer is unlikely to respond to therapies that target progesterone pathways.

Use this code when laboratory or pathology reports confirm the absence of progesterone receptors in a malignant neoplasm. This is commonly applied in the context of breast cancer staging and treatment planning, where receptor status guides therapeutic decisions. It should be assigned as a secondary diagnosis to provide further specificity about the tumor's characteristics.

• Always assign this code in conjunction with the definitive malignancy code.
• Ensure the pathology report explicitly states "progesterone receptor negative" or similar terminology.
• Do not use this code if the receptor status is unknown, equivocal, or positive.