Secondary syphilis, relapse

This code signifies a recurrence of secondary syphilis after a period of remission, indicating that the initial treatment was either ineffective or the infection was reacquired. Secondary syphilis is characterized by systemic symptoms such as skin rashes, mucocutaneous lesions, lymphadenopathy, and flu-like symptoms. A relapse means these manifestations have reappeared.

Use this code when a patient previously diagnosed and treated for secondary syphilis presents with new or recurring signs and symptoms consistent with the secondary stage of the disease. Documentation should clearly state "secondary syphilis, relapse" or describe the reappearance of characteristic secondary syphilitic lesions or symptoms following a period of resolution.

• Ensure documentation explicitly states "relapse" to differentiate from initial secondary syphilis.
• Confirm serological evidence (e.g., rising RPR/VDRL titers) supports a relapse rather than a new infection.
• Do not confuse with primary syphilis, latent syphilis, or tertiary syphilis, which have distinct clinical presentations and codes.