Hemoglobinuria due to hemolysis from external causes

This code signifies the presence of hemoglobin in the urine, specifically when it results from the breakdown of red blood cells (hemolysis) caused by external factors. It indicates a hemolytic process triggered by an exogenous agent or event, leading to the release of hemoglobin into the bloodstream and subsequent excretion via the kidneys.

Use this code when documentation clearly links hemoglobinuria to an external cause of hemolysis, such as drug-induced hemolytic anemia, exposure to toxins, or mechanical trauma to red blood cells (e.g., from prosthetic heart valves). Supporting documentation should specify both the presence of hemoglobinuria and the identified external hemolytic agent or event.

• Always identify and code the underlying external cause of hemolysis first, if known, using an E-code.
• Differentiate from paroxysmal nocturnal hemoglobinuria (PNH) or other intrinsic causes of hemolysis.
• Ensure documentation specifies hemoglobinuria and not just hematuria (blood in urine), as the latter has different underlying causes.