Functional disorders of polymorphonuclear neutrophils

This code represents a group of intrinsic defects affecting the normal function of polymorphonuclear neutrophils (PMNs), a type of white blood cell crucial for the immune response. These disorders impair the PMNs' ability to effectively phagocytose, kill, or migrate to sites of infection, leading to increased susceptibility to recurrent bacterial and fungal infections.

Use this code when documentation indicates a diagnosed functional impairment of neutrophils, such as chronic granulomatous disease (CGD), myeloperoxidase deficiency, or leukocyte adhesion deficiency. Supporting documentation should include laboratory findings demonstrating abnormal neutrophil function tests (e.g., NBT test, DHR assay) and a history of recurrent severe infections.

• Ensure the documentation clearly specifies a functional disorder of neutrophils, not merely a quantitative abnormality (e.g., neutropenia).
• Always look for specific genetic diagnoses or enzyme deficiencies that underpin these functional defects, as these may have more specific codes if available in the current code set.
• Sequence this code as a primary diagnosis when the functional neutrophil disorder is the reason for the encounter, or as a secondary diagnosis when it contributes to the patient's overall condition or management of recurrent infections.