Hypersplenism

This code represents a condition characterized by an enlarged spleen (splenomegaly) and a reduction in one or more types of blood cells (cytopenias), such as anemia, leukopenia, or thrombocytopenia. The enlarged spleen prematurely destroys these blood cells, leading to their decreased levels in circulation.

Use this code when documentation clearly indicates a diagnosis of hypersplenism, often presenting with splenomegaly and associated cytopenias. Supporting documentation should include laboratory findings confirming low blood cell counts and imaging studies demonstrating an enlarged spleen.

• Always code the underlying cause of the hypersplenism first, if known (e.g., portal hypertension, lymphoma).
• Do not confuse with simple splenomegaly (789.2) without evidence of increased splenic destruction of blood cells.
• Ensure the medical record explicitly states "hypersplenism" or describes the characteristic triad of splenomegaly, cytopenia, and hyperactive splenic function.