Prolymphocytic leukemia of B-cell type not achieve remission

This code signifies a malignant proliferation of B-lymphocytes, specifically prolymphocytes, that has not responded to initial treatment or has relapsed. It represents an aggressive form of chronic lymphocytic leukemia (CLL) characterized by a high percentage of prolymphocytes in the peripheral blood and bone marrow. The "not having achieved remission" indicates the disease is still active and uncontrolled.

Apply this code when documentation confirms a diagnosis of B-cell prolymphocytic leukemia (B-PLL) and explicitly states that the patient is not in remission. This typically occurs during initial diagnosis, after failed induction therapy, or during a relapse where the disease is still active. Supporting documentation includes pathology reports, hematology consultations, and treatment summaries indicating ongoing disease activity.

• Ensure the documentation clearly specifies "B-cell type" and the absence of remission.
• Do not confuse with C91.31 (in remission) or C91.32 (in relapse).
• Always sequence this code as the primary diagnosis when it is the reason for the encounter.