Immune effector cell-associated neurotoxicity synd, grade 1

This code describes a mild form of neurological toxicity that can occur after treatment with immune effector cells, such as CAR T-cell therapy. It encompasses symptoms like attention deficits, mild language difficulties, or motor weakness that do not significantly interfere with daily activities. This grade indicates the least severe manifestation of immune effector cell-associated neurotoxicity syndrome (ICANS).

Assign this code when documentation clearly indicates a diagnosis of ICANS with a severity grade of 1, following immune effector cell therapy. This diagnosis is typically made by the treating oncologist or neurologist based on clinical assessment and specific grading scales (e.g., ASTCT consensus grading).

• Ensure the documentation explicitly states "grade 1" neurotoxicity; avoid using for unspecified or higher grades.
• Always sequence this code after the code for the underlying malignancy being treated.
• Do not confuse with other neurological complications not directly attributed to immune effector cell therapy.