Immune effector cell-associated neurotoxicity synd, grade 2

Immune effector cell-associated neurotoxicity syndrome, grade 2

📋Clinical Description

This code signifies a moderate form of neurological toxicity specifically linked to immune effector cell (IEC) therapies, such as CAR T-cell therapy. Patients present with symptoms like aphasia, generalized weakness, or seizures, but are generally able to perform basic activities of daily living.

🎯When to Use

Apply this code when documentation clearly indicates a patient receiving immune effector cell therapy has developed neurotoxicity classified as Grade 2 based on established grading scales (e.g., ASTCT consensus grading). This typically involves new onset neurological symptoms that are more than mild but do not require intubation or significant vasopressor support.

💡Coding Tips

Ensure the documentation explicitly states "Grade 2" neurotoxicity or provides sufficient detail to support this grading.
Distinguish from other grades of IEC-associated neurotoxicity; higher or lower grades have distinct codes.
Code the underlying malignancy and the specific immune effector cell therapy as additional diagnoses.

AI-generated reference — verify against official guidelines

Clinical Notes

Inclusion Terms

ICANS, grade 2

Code Hierarchy

▲G92.0Immune effector cell-associated neurotoxicity syndrome

G92.02(current)

Same Category

G92Toxic encephalopathy G92.0Immune effector cell-associated neurotoxicity syndrome G92.00Immune effor cell-associated neurotoxicity synd, grade unsp G92.01Immune effector cell-associated neurotoxicity synd, grade 1 G92.03Immune effector cell-associated neurotoxicity synd, grade 3 G92.04Immune effector cell-associated neurotoxicity synd, grade 4