Angelman syndrome

This code identifies Angelman syndrome, a neurodevelopmental disorder characterized by severe developmental delay, intellectual disability, speech impairment, ataxia, and a uniquely happy demeanor. It is typically caused by a deletion or mutation on chromosome 15.

Assign this code for patients diagnosed with Angelman syndrome based on genetic testing confirming the characteristic chromosomal abnormality or a strong clinical presentation. Documentation should clearly state the diagnosis of Angelman syndrome.

• Do not confuse with Prader-Willi syndrome (Q87.11), which involves a different genetic mechanism on the same chromosome.
• Always look for genetic testing results or a definitive clinical diagnosis in the medical record.
• Code any associated neurological manifestations or comorbidities separately.