Deletions with other complex rearrangements

This code describes a chromosomal abnormality characterized by the loss of genetic material (deletion) combined with other complex structural changes within the chromosome. These rearrangements can involve inversions, translocations, or duplications occurring simultaneously with the deletion, leading to a significant alteration of the genetic makeup. This often results in a syndromic presentation with various developmental and intellectual disabilities.

Assign this code when documentation explicitly states a chromosomal deletion co-occurs with other complex structural rearrangements, such as an inversion or translocation. This typically follows genetic testing (e.g., karyotyping, FISH, microarray) confirming the specific complex chromosomal anomaly. Use this code when the specific type of complex rearrangement is not further specified by a more precise code.

• Ensure documentation clearly distinguishes between simple deletions and those involving additional complex rearrangements.
• Do not use this code for isolated deletions or other isolated chromosomal abnormalities; look for more specific codes.
• Sequence this code as a primary diagnosis when it is the underlying cause of the patient's condition.