SIRS of non-infectious origin w/o acute organ dysfunction

This code signifies a widespread inflammatory response throughout the body that is not caused by an infection. It indicates the presence of at least two of the SIRS criteria (e.g., fever or hypothermia, tachycardia, tachypnea, abnormal white blood cell count) in the absence of an identified infectious source and without any associated organ damage.

Use this code when a patient exhibits signs of systemic inflammation, such as those meeting SIRS criteria, but a thorough workup has ruled out an infectious etiology. Documentation should clearly state "SIRS of non-infectious origin" and confirm the absence of acute organ dysfunction. This code is often applicable in cases of severe pancreatitis, trauma, burns, or other sterile inflammatory conditions.

• Always ensure documentation explicitly states "non-infectious origin" and "without acute organ dysfunction" to support this specific code.
• Do not use this code if an infection is identified as the cause of SIRS; instead, code the underlying infection and R65.20 or R65.21 for SIRS with organ dysfunction.
• This code should be sequenced after the underlying condition causing the non-infectious SIRS (e.g., severe pancreatitis).