Hormone recept neg w hmn epdrml grth fctr recept 2 pos stat

This code describes a specific subtype of breast cancer characterized by the absence of estrogen and progesterone receptors, but the overexpression of the HER2 protein. This receptor status indicates a more aggressive tumor that may respond to targeted HER2 therapies.

Apply this code for patients diagnosed with breast cancer where pathology reports confirm both hormone receptor negativity (ER- and PR-) and HER2 positivity. This is typically used in conjunction with a primary malignancy code for the breast.

• Always confirm the receptor status directly from the pathology report.
• Do not use this code if the HER2 status is negative or unknown.
• This code is a secondary diagnosis and must be linked to a primary malignancy code (e.g., C50.-).